CF076 - Métodos Bioquímicos e Biofísicos Aplicados à Pesquisa de Fármacos - 2S/2026 Imprimir

Ementa:

A disciplina visa introduzir o conceito de High-Throughput Screening (HTS) e sua aplicação nas etapas iniciais do processo de pesquisa e descoberta de novos candidatos a fármacos e desenvolvimento pré-clínico.

Bibliografia:

1. Janzen, W. P., Bernasconi, P. High throughput screening: methods and protocols. 2 ed. New York: Humana Press, 2009.
2. Janzen, W. P. High throughput screening: methods and protocols. 3 ed. New York: Humana Press, 2016.
3. Sittampalam GS, Grossman A, Brimacombe K., et al. Assay guidance manual. Bethesda (MD): Eli Lilly & Company and the National Center for Advancing Translational Sciences, 2004-. Disponível em: https://www.ncbi.nlm.nih.gov/books/NBK53196/.
4. Copeland R. A. Evaluation of Enzyme Inhibitors in Drug Discovery: A guide for medicinal chemists and Pharmacologists. 2 ed: Wiley-Interscience, 2013.
5. Hughes, J. P. et al. Principles of early drug discovery. British journal of pharmacology, v. 162, n. 6, p. 1239-1249, 2011.
6. Macarron, R. et al. Impact of high-throughput screening in biomedical research. Nature Reviews Drug Discovery, v. 10, n. 3, p. 188-195, 2011.
7. Patrick, G.L. An Introduction to Medicinal Chemistry. 6th ed., Oxford University Press, 2017.
8. Stoyanov, E. S. NMR Spectroscopy in Drug Development and Analysis. Wiley, 2019.
9. Snyder, L.R. et al. Introduction to Modern Liquid Chromatography. 3rd ed., Wiley, 2010.
10. Testa, B. et al. Drug Metabolism: Chemical and Enzymatic Aspects. Wiley, 2019.
11. Watson, J.T. Introduction to Mass Spectrometry: Instrumentation, Applications, and Strategies for Data Interpretation. 5th ed., Wiley, 2019.
Outras referências específicas serão indicadas ao longo da disciplina.

Ano de Catálogo: 2026

Créditos: 2